A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene
Identifieur interne : 000A04 ( Main/Exploration ); précédent : 000A03; suivant : 000A05A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene
Auteurs : Sheila N. Jani Sait [États-Unis] ; Susana C. Raimondi [États-Unis] ; A. Thomas Look [États-Unis] ; Heidi Gill [États-Unis] ; Michael Thirman [États-Unis] ; Manuel O. Diaz [États-Unis] ; Thomas B. Shows [États-Unis]Source :
- Genes, Chromosomes and Cancer [ 1045-2257 ] ; 1993-05.
English descriptors
- Teeft :
- Acute leukemia, Acute leukemias, Acute lymphoblastic leukemia, Acute myeloid leukemia, Bamhi, Bamhi fragment, Bone marrow, Bone marrow cells, Breakpoint, Breakpoints, Cd3d, Cell hybrids, Chromosome, Chromosome band, Chromosome translocation, Clone, Drosophih trithorax, Drosophila trithorax protein, Homeotic gene regulation, Human gene mapping, Human genetics, Human homolog, Hybrid, Jani sait, Leukemia, Leukemic, Leukemic cells, Lymphoblastic, Lymphoblastic leukemia, Monocytic, Pbr3, Pbr6, Polyethylene glycol, Probe hybridized, Proc natl acad, Rearrangement, Roswell park cancer institute, Somatic cell hybrids pbr3, Southern blot analysis, Translocation, Translocation breakpoints.
Abstract
Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed‐lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene. © 1993 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/gcc.2870070105
Affiliations:
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Le document en format XML
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Jani" last="Sait">Sheila N. Jani Sait</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Correspondence address: Roswell Park Cancer Institute, Department of Human Genetics, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Raimondi, Susana C" sort="Raimondi, Susana C" uniqKey="Raimondi S" first="Susana C." last="Raimondi">Susana C. Raimondi</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>St. Jude Children's Research Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Look, A Thomas" sort="Look, A Thomas" uniqKey="Look A" first="A. Thomas" last="Look">A. Thomas Look</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>St. Jude Children's Research Hospital, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Gill, Heidi" sort="Gill, Heidi" uniqKey="Gill H" first="Heidi" last="Gill">Heidi Gill</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Thirman, Michael" sort="Thirman, Michael" uniqKey="Thirman M" first="Michael" last="Thirman">Michael Thirman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Diaz, Manuel O" sort="Diaz, Manuel O" uniqKey="Diaz M" first="Manuel O." last="Diaz">Manuel O. Diaz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Shows, Thomas B" sort="Shows, Thomas B" uniqKey="Shows T" first="Thomas B." last="Shows">Thomas B. Shows</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Human Genetics, Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Genes, Chromosomes and Cancer</title><title level="j" type="alt">GENES, CHROMOSOMES AND CANCER</title><idno type="ISSN">1045-2257</idno><idno type="eISSN">1098-2264</idno><imprint><biblScope unit="vol">7</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="28">28</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">4</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1993-05">1993-05</date></imprint><idno type="ISSN">1045-2257</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1045-2257</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute leukemia</term><term>Acute leukemias</term><term>Acute lymphoblastic leukemia</term><term>Acute myeloid leukemia</term><term>Bamhi</term><term>Bamhi fragment</term><term>Bone marrow</term><term>Bone marrow cells</term><term>Breakpoint</term><term>Breakpoints</term><term>Cd3d</term><term>Cell hybrids</term><term>Chromosome</term><term>Chromosome band</term><term>Chromosome translocation</term><term>Clone</term><term>Drosophih trithorax</term><term>Drosophila trithorax protein</term><term>Homeotic gene regulation</term><term>Human gene mapping</term><term>Human genetics</term><term>Human homolog</term><term>Hybrid</term><term>Jani sait</term><term>Leukemia</term><term>Leukemic</term><term>Leukemic cells</term><term>Lymphoblastic</term><term>Lymphoblastic leukemia</term><term>Monocytic</term><term>Pbr3</term><term>Pbr6</term><term>Polyethylene glycol</term><term>Probe hybridized</term><term>Proc natl acad</term><term>Rearrangement</term><term>Roswell park cancer institute</term><term>Somatic cell hybrids pbr3</term><term>Southern blot analysis</term><term>Translocation</term><term>Translocation breakpoints</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed‐lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene. © 1993 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li><li>Tennessee</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Sait, Sheila N Jani" sort="Sait, Sheila N Jani" uniqKey="Sait S" first="Sheila N. Jani" last="Sait">Sheila N. Jani Sait</name></region><name sortKey="Diaz, Manuel O" sort="Diaz, Manuel O" uniqKey="Diaz M" first="Manuel O." last="Diaz">Manuel O. Diaz</name><name sortKey="Gill, Heidi" sort="Gill, Heidi" uniqKey="Gill H" first="Heidi" last="Gill">Heidi Gill</name><name sortKey="Look, A Thomas" sort="Look, A Thomas" uniqKey="Look A" first="A. Thomas" last="Look">A. Thomas Look</name><name sortKey="Raimondi, Susana C" sort="Raimondi, Susana C" uniqKey="Raimondi S" first="Susana C." last="Raimondi">Susana C. Raimondi</name><name sortKey="Sait, Sheila N Jani" sort="Sait, Sheila N Jani" uniqKey="Sait S" first="Sheila N. Jani" last="Sait">Sheila N. Jani Sait</name><name sortKey="Shows, Thomas B" sort="Shows, Thomas B" uniqKey="Shows T" first="Thomas B." last="Shows">Thomas B. Shows</name><name sortKey="Thirman, Michael" sort="Thirman, Michael" uniqKey="Thirman M" first="Michael" last="Thirman">Michael Thirman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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